Spatio-Temporal Registration of the Expression Patterns of Drosophila Segmentation Genes

Ekaterina M. Myasnikova, David Kosman, John Reinitz, and Maria G. Samsonova

The application of image registration techniques resulted in the construction of an integrated atlas of Drosophila segmentation gene expression in both space and time. The registration method was based on a quadratic spline approximation with flexible knots. A classifier for automatic attribution of an embryo to one of the temporal classes according to its gene expression pattern was developed.

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